Outcomes of Other Medicines on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (key route) and CYP2C9 (small route). As a result, inhibitors of these isoenzymes may possibly lessen sildenafil clearance and inducers of these isoenzymes might increase sildenafil clearance.Even though sildenafil enhances some markers of sickness in thos